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VIAGRA originele 100mg



VIAGRA originele 100mg

Sildenafil brand 20mg is a drug that is used in the management of erectile dysfunction in men. It belongs to PDE5 inhibitor group as it has selective inhibitory action on an enzyme known as PDE5 or phosphodiesterase Type 5.

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VIAGRA originele 100mg

VIAGRA originele 100mg Viagra brand 20mg is a drug that is used in the management of erectile dysfunction in men. It belongs to PDE5 inhibitor group as it has selective inhibitory action on an enzyme known as PDE5
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Sildenafil brand 20mg

Sildenafil is a drug that is used in the management of erectile dysfunction in men. It belongs to PDE5 inhibitors group which has selective inhibitory action on an enzyme known as PDE5 or phosphodiesterase Type 5.

Sildenafil brand 20mg Mechanism of Action

Sildenafil is the active constituent of Sildenafil. It has selective inhibitory action on an enzyme known as PDE5. The usual erection of the penis occurs when with sexual arousal there is nitric oxide release. This will result in elevated level of cGMP causing relaxation of the penile smooth muscles present in the cavernous body. Sildenfil will not cause any direct effect on corpus cavernosum and cause its relaxation but will do so by the indirect method of preventing the breakdown of cGMP by preventing the actions of PDE5.

This will in turn enhance the effects of the present cGMP thus enabling the person to retain the erection for a longer duration of time thus helping in achieving sexual intercourse.

Sildenafil brand 20mg Contraindication for Use

Sildenafil is not advisable for use in the given conditions:

  • The person has a known allergy or hypersensitivity to any of the constituents of the medication including its active constituent.
  • The combined use of Sildenafil with other drugs indicated for the management of erectile dysfunction. The efficacy and safety of such combinations have not been established and is therefore not advisable.
  • The medication is contraindicated for use in women, children and adolescents below the age of 18
  • The simultaneous use of Sildenafil with nitrates or donors of nitrogen oxide is not advisable.

Sildenafil Cautions and Contraindications

Extreme caution should be taken to use Sildenafil in the following conditions:

  • Penile deformation such as Peyronie’s disease, angulation or cavernous fibrosis
  • Priapism
  • Conditions that have the high risk of Priapism such as multiple myeloma, sickle cell anemia, thrombocytemia or leukemia
  • Bleeding disorders
  • Retinitis pigmentosa, a rare hereditary condition of the eye
  • Stomach ulcers or ulcers of the duodenum

Sildenafil brand 20mg Dosage

The medication is taken through oral route. The usual advised dose is 50mg consumed about an hour prior to sexual intercourse. The dose might be adjusted to 100 mg or 25 mg depending on the therapeutic effects. It is not advisable to take the drug more than once in the period of 24 hours.

In cases of kidney failure of mild or moderate nature no dose changes are needed. But, in severe cases of kidney failure, the dose of Sildenafil will need to be adjusted to 25mg / day. The same holds good in cases of Liver failure.

If the drug is used simultaneously with ritonavir the dose should not be beyond 25 mg and must not be taken more than once in the period of 48 hours. If the person is taking any medications such as erythromycin, itraconazole, saquinavir, or ketoconazole, the starting dose of Sildenafil must be 25mg.

If the person is on alpha blocker drugs, the use of Sildenafil must be with caution and it is essential to stabilize hemodynamics prior to starting off on the drug.

Sildenafil brand Adverse Effects

Sildenafil is commonly tolerated well by all those who take it with few experiencing adverse effects. The most commonly seen adverse effects will include headache (16%), facial flushing and hot flashes (10%), dyspepsia and nasal congestion (4%), urinary tract infections (3%), vision disturbances (photosensitivity, vision blurring and disturbances in color vision) and diarrhea (3%), skin rashes and dizziness (2%).

Rarely seen adverse effects with Sildenafil include joint pain, infections of the respiratory tract, back pain, rhinitis, and flu-like symptoms.

If higher dose of Sildenafil is taken the following adverse effects might be seen:

  • Signs of hypersensitivity such as skin rashes
  • Seizures
  • Vomiting
  • Elevated heart rate, feeling faint, reduced blood pressure
  • Bleeding from nose
  • Redness of the eye with pain.

In extremely rare cases, the use of the medication could result in adverse effects such as asthma, agitation, arthritis, anemia, angina pectoris, fear, insomnia, depression, gout, dryness of the mouth, migraine, urinary incontinence, muscle pain, depression and transient loss of vision.

No correlation between cardiovascular events like heart attack or stroke with the use of Sildenafil has been established.

Sildenafil brand 20mg Drug Interactions

It is necessary to tell the doctor about any medicines the person is taking while undergoing assessment prior to taking Sildenafil. This is essential as there might be some untoward drug interactions that might cause complications. Some of the drug interactions with Sildenafil include:

The use of concomitant Sildenafil with nitrates or donors of nitrogen oxide might lead to drastic reduction in blood pressure.

The use of concomitant Sildenafil and Cimetidine, a histamine receptor blocker could lead to increased level of Sildenafil in the blood as metabolism of the drug might get affected.

Use of antiviral drugs such as ritonavir along with Sildenafil can cause elevated levels of Sildenafil in the blood as the antiviral drug could affect the metabolism of sildenafil.

If Sildenafil is used simultaneously with calcium channel blocker drugs like Amlodipine there could be drastic reduction in the blood pressure.

The use of Sildenafil with alpha blocker drug could also cause severe drop in the blood pressure.

The use of macrolide antibiotics like erythromycin simultaneously with Sildenafil might affect the metabolism of the latter causing elevated blood levels.

The metabolism of Sildenafil might get affected with concomitant use of antifungal medications such as Fluconazole and Ketoconazole leading to decreased elimination from the body thereby increasing the risk of occurrence of adverse effects of Sildenafil.

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